The convergence of type 1 and type 2 diabetes in childhood The accelerator hypothesis
Pediatric Diabetes, 04/20/2012
Wilkin TJ – It seems likely that type 1 and type 2 diabetes lie at different points of the same spectrum, separated by the misunderstanding that one belongs to childhood and the other to adulthood. The spectrum is that of tempo – the rate at which beta cell function is lost over time. A combination of beta cell up–regulation (insulin demand, largely determined by obesity) and the genetically–determined immune response to it (‘autoimmunity’) determines tempo, ranging from slow to fast with every variant in between.
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