Alveolar concentration and bronchial flux of nitric oxide: Two linear modeling methods evaluated in children and adolescents with allergic rhinitis and atopic asthma

Pediatric Pulmonology, 04/18/2012

Chládková J et al. – The results show that fraction of NO in orally exhaled air (FENO) has to be measured at several expiratory flows >100ml/sec for the accurate estimation of Alveolar concentration (CANO) and JawNO using linear methods P and T in children and adolescents with atopic asthma (AA) and allergic rhinitis (AR). A stepwise procedure for detecting nonlinearity and evaluating the quality of FENO measurements is suggested.

Methods

  • Measurements of FENO were performed with a chemiluminiscence analyzer at five levels of V ranging from 50 to 250ml/sec in school children and adolescents with mild to moderate-severe AA treated by inhaled corticosteroids (N=42) and AR (N=20).

Results

  • The results show that FENO has to be measured at several expiratory flows >100ml/sec for the accurate estimation of CANO and JawNO using linear methods P and T in children and adolescents with AA and AR.
  • A stepwise procedure for detecting nonlinearity and evaluating the quality of FENO measurements is suggested.

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