An independent effect of parental lipids on the offspring lipid levels in a cohort of adolescents with type 1 diabetes

Pediatric Diabetes, 03/20/2012

Marcovecchio ML et al. – In the present study, parental lipid levels were independently associated with the same traits in the offspring, suggesting a role of genetic influences and/or shared environmental factors in modulating the metabolic profile of adolescents with type 1 diabetes (T1D). In contrast, there was no significant association between parental lipid levels and the offspring's albumin excretion.

Methods

  • Non-fasting blood samples were collected from 895 offspring, 808 mothers and 582 fathers.
  • Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and non-HDL-C were measured.
  • Three early morning urinary albumin–creatinine ratios (ACR), hemoglobin A1C (HbA1c) and anthropometric parameters were also assessed.

Results

  • The offspring's mean age (±SD) was 14.5 ± 2.2 yr, mean diabetes duration 5.5 ± 3.7 yr; the fathers' age was 45.7 ± 6.1 yr and the mothers' age was 42.8 ± 5.5 yr.
  • After adjusting for the offspring age, gender, body mass index, HbA1c, maternal and paternal lipid levels were significantly associated with the offspring's lipid parameters.
  • In contrast, no significant association was found between parental lipid levels and the offspring's ACR.

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