An independent effect of parental lipids on the offspring lipid levels in a cohort of adolescents with type 1 diabetes
Pediatric Diabetes, 03/20/2012
Marcovecchio ML et al. – In the present study, parental lipid levels were independently associated with the same traits in the offspring, suggesting a role of genetic influences and/or shared environmental factors in modulating the metabolic profile of adolescents with type 1 diabetes (T1D). In contrast, there was no significant association between parental lipid levels and the offspring's albumin excretion.
Non-fasting blood samples were collected from 895 offspring, 808 mothers and 582 fathers.
Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and non-HDL-C were measured.
Three early morning urinary albumin–creatinine ratios (ACR), hemoglobin A1C (HbA1c) and anthropometric parameters were also assessed.
The offspring's mean age (±SD) was 14.5 ± 2.2 yr, mean diabetes duration 5.5 ± 3.7 yr; the fathers' age was 45.7 ± 6.1 yr and the mothers' age was 42.8 ± 5.5 yr.
After adjusting for the offspring age, gender, body mass index, HbA1c, maternal and paternal lipid levels were significantly associated with the offspring's lipid parameters.
In contrast, no significant association was found between parental lipid levels and the offspring's ACR.
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