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Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children
Cancer Chemotherapy and Pharmacology, 10/29/09

Conroy S et al. – The pre–determined criteria were not applicable, in their entirety, in the majority of drugs, due to lack of information in the academic domain, emphasising the importance of a more open approach for sharing basic drug information. The prioritised list of 12 candidate drugs for clinical trial and 15 for pre–clinical investigation justify that a concerted research effort in this area of practice is made.

Exclusive Author Commentary
David Walker, 10/29/09

This work was stimulated by the observation of the considerable brain and skeletal injury,currently suffered by young children treated by cranio spinal radiotherapy for medulloblastoma. The efficacy of systemic chemotherapy is limited by systemic toxicity and drug access to the central nervous system. Intrathecal chemotherapy has been used successfully in medulloblastoma and in ALL producing the excellent control of CNS disease. We decided to review established chemotherapy agents for efficacy against medulloblastoma and suitability for intrathecal administration. The systematic literature review identified a major gap in the availability of information about pharmacological characteristics of established drugs whilst also testing criteria for drug selection and then applying these where possible, and where not, using whatever information that was avaialble to select and rank drugs for future testing in this clinical condition. This review will stimulate debate regarding drug selection and promote a renewed interest in the use of this route of drug administration. It would be a remarkable response if Pharma and Academia agreed to share basic pharmacological information about their new and old cancer drugs in a systematic and open fashion.

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Incomplete Penetrance of the Predisposition to Medulloblastoma Associated With Germ-Line Sufu Mutations
Journal of Medical Genetics, 10/29/09 Relevance Score: 88%

Analysis of microsatellite instability in medulloblastoma
Neuro-Oncology, 10/07/09 Relevance Score: 88%

The Alkylphospholipid Perifosine Induces Apoptosis and p21-Mediated Cell Cycle Arrest in Medulloblastoma
Molecular Cancer Research, 11/06/09 Relevance Score: 83%

A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma
Medical Oncology, 10/09/09 Relevance Score: 82%

Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors
Journal of Neuro-Oncology, 10/01/09 Relevance Score: 82%