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Angiotensin converting enzyme DD genotype is associated with development of rheumatic heart disease in Egyptian children
Rheumatology International, 10/28/09

Morsy MMF et al. –This study was conducted to demonstrate this gene polymorphism in Egyptian children with RHD. Leukocytes DNA was extracted We concluded that patients with RHD have a higher ACE-DD genotype than normal control. ACE-DD genotype may be a risk factor for RHD in Egyptian children.

• Leukocytes DNA extracted from 139 patients with RHD and 79 healthy control children
• After amplification by PCR, the products were separated by electrophoresis in 6% polyacrylamide gel and visualized after ethidium bromide staining with UV light

• Gene polymorphism in both control and patients groups followed the following order of distribution from highest to lowest: ID, II, DD gene
• Frequency in control group was 49.4, 36.7, and 13.9%, respectively
• In patients groups, the gene frequency was 42.5, 30.9, and 26.6%, respectively
• DD gene frequency differs significantly between the 2 groups

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