Pediatrics Medical News about temozolomide

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MGMT as a potential stratification marker in relapsed high-grade glioma of children: The HIT-GBM experience
Pediatric Blood & Cancer, 11/03/09

Schlosser S et al. – DNA methylation, but not protein expression of MGMT was associated with an increased median EFS and OS of children with relapsed HGG. MGMT methylation status warrants prospective evaluation as a stratification marker for children with HGG.

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A Phase II Study of Cisplatin and Temozolomide in Heavily Pre-treated Patients with Temozolomide-refractory High-grade Malignant Glioma
Anticancer Research, 11/13/09 Relevance Score: 89%

Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status
Journal of Neuro-Oncology, 10/27/09 Relevance Score: 87%

Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme
Expert Review of Anticancer Therapy, 11/12/09 Relevance Score: 84%

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
Journal of Clinical Oncology, 11/12/09 Relevance Score: 84%

Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma
Neuro-Oncology, 10/06/09 Relevance Score: 84%