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When should we be conducting thyroid function tests in newborns and young infants
BMJ - Archives of Diseases in Childhood, 10/26/09

Ogundele MO et al. – The highest proportion of all the tests was performed as routine investigation of prolonged neonatal jaundice. Other common indications were maternal thyroid disorders and suspected neonatal thyroid disorders. There was no confirmed diagnosis of infantile thyroid disease.

Exclusive Author Commentary
Michael O Ogundele, 10/27/09

Our current study suggests that too many laboratory tests of thyroid functions (TFT) are being unnecessarily performed in neonates and young infants. Laboratory workload for TFT that are potentially avoidable include repeat Congenital Hypothyroidism screen testing in preterm babies, screening of babies with prolonged jaundice, postnatal screening of babies born to hypothyroid and thyrotoxic mothers. Repeat testing is not only costly in terms of anxiety for parents, it is an unpleasant procedure for the baby and for all involved in obtaining and analysing the samples. Large audits of screening programmes for infants with prolonged jaundice have confirmed insignificant clinical yield from TFT results. There are several potential areas of cost containment and significant savings with regard to laboratory testing of thyroid functions in newborns and early infancy.

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