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Ethnic differences in pediatric systemic lupus erythematosus
Journal of Rheumatology, 10/21/09

Hiraki LT et al. – Non-Caucasian ethnicity is associated with increased pSLE disease prevalence. Non-Caucasian pSLE patients were significantly younger and more likely to have nephritis. However, disease activity and damage were strongly associated with major organ disease independent of the patient’s ethnicity.

• Ethnic demographic profiles of inception cohort of 265 patients with pSLE followed at Sick Kids Hospital in Toronto determined and compared to Metropolitan Toronto at-risk population
• Patients categorized into ethnic subsets based on self-designated ethnic origins
• Disease characteristics including major organ involvement, disease activity, and damage measures longitudinally determined and compared among ethnic groups

• Ethnicity data available on 259/265 pSLE patients (99.6%); the majority were non-Caucasian (60%) compared to Metropolitan Toronto at-risk population (40%)
• Non-Caucasian patients younger at diagnosis than Caucasian patients, Black patients being youngest at diagnosis
• Renal disease significantly more common in non-Caucasian than Caucasian pSLE patients
• Trend toward increased prevalence of CNS disease in Black patients compared to Asian patients
• No difference in gender ratio, SLE Disease Activity Index, or damage scores between ethnic groups

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