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Genetic polymorphisms of IL-6-174 and IL-10-1082 in full term neonates with late onset blood stream infections
Journal of Pediatric Infectious Diseases, 10/15/09
Abdel–Hady H et al. – The IL–6 –174 CC and IL–10 –1082 GG genotypes were associated with increased risk for mortality, need for inotropic support and development of disseminated intravascular coagulopathy in full–term neonates with BSIs. These findings suggest that the genetic composition of the IL–6 and IL–10 promoter areas play a significant role in the pathogenesis of neonatal BSIs.
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