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See Latest ArticlesDoes BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies
International Journal of Epidemiology, 10/14/09
El–Zein M et al. – These results strengthen the epidemiological evidence in support of the hypothesis that exposure to the BCG vaccine in early life prevents asthma, possibly through a modulation of the immune maturation process.
Methods- Eligible studies were identified using a search strategy that included a computerized literature search and a manual search of each article's reference list, up to June 2008.
- A total of 23 studies were included (10 cohort, 5 case–control and 8 cross–sectional). Each study was summarized and rated for methodological quality.
- Three indicators of BCG exposure were considered including BCG vaccination, tuberculin response and scar diameter.
- The pooled estimate of association for 23 studies reporting on any of the three indicators suggested a protective effect of BCG exposure on childhood asthma occurrence.
- The studies were heterogeneous, especially when tuberculin response was considered.
- Restriction to a subgroup of 16 studies that considered BCG vaccination indicated a protective effect with no evidence of heterogeneity.
- The overall pooled OR using an FE model was 0.86. Exclusion of three studies with the lowest quality scores showed a similar association.
Today in Epidemiology...keeping you current
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Clinical Presentation of Rheumatic Fever in an Endemic Area
BMJ - Archives of Diseases in Childhood, 11/12/09
Pediatric Burn Injuries Treated in US Emergency Departments Between 1990 and 2006
Pediatrics, 10/30/09
Autism Spectrum Disorders in Preschool-Aged Children: Prevalence and Comparison to a School-Aged Population
Annals of Epidemiology , 10/13/09
Today in Pediatric Pulmonology...keeping you current
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Pediatric Asthma: An Integrative Approach to Care
Nutrition in Clinical Practice, 10/22/09
Anti-inflammatory drug therapy in asthma
Paediatric Respiratory Reviews, 11/02/09
Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department
Cochrane Reviews, 10/26/09
Today in Peds Allergy/Immunology...keeping you current
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Role of adenoids and adenoiditis in children with allergy and otitis media
Current Allergy and Asthma Reports, 10/22/09
Update on vaccination guidelines for allergic children
Expert Review of Vaccines, 10/29/09
Pediatric Asthma: An Integrative Approach to Care
Nutrition in Clinical Practice, 10/22/09
Today in Preventive/Nutrition...keeping you current
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Antibiotic Use in Neonatal Intensive Care Units and Adherence With Centers for Disease Control and Prevention 12 Step Campaign to Prevent Antimicrobial Resistance
The Pediatric Infectious Disease Journal, 10/29/09
Cost effectiveness analysis of including boys in a human papillomavirus vaccination programme in the United States
British Medical Journal, 10/22/09
Efficacy of a single dose of live attenuated influenza vaccine in previously unvaccinated children: A post hoc analysis of three studies of children aged 2 to 6 years
Clinical Therapeutics, 11/19/09
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