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Slavin TP et al. – Early recognition of a possible underlying genetic defect with a resultant diagnostic work–up can lessen or prevent tumor burden, improve screening for possible cancer recurrence, and optimize care for children and their family members. Important clues from the history and physical include a family history of cancer, a specific cancer type frequently associated with a genetic defect, synchronous or metachronous cancers in the same individual, growth abnormalities, abnormal skin pigmentation, and/or thumb/radius malformations.


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