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Urotensin-II contributes to pulmonary vasoconstriction in a perinatal model of persistent pulmonary hypertension of the newborn secondary to meconium aspiration syndrome
Pediatric Research, 10/07/09
Simpson CM et al. – These findings suggest that U–II normally acts as a pulmonary vasodilator after birth, but in the presence of MAS, it assumes a vasoconstrictor role. U–II receptor blockade also improves pulmonary hemodynamics in this model.
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