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See Latest ArticlesPhenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
Arthritis Research & Therapy, 10/06/09
Corcione A et al. – This study demonstrates for the first time an expansion of activated switch memory B cells and of IgG-secreting plasma blasts in the SF from oligoarticular JIA patients. Memory B cells belonged to either the CD27+ or the CD27- subsets and expressed CD86, suggesting their involvement in antigen presentation to T cells. Patterns of chemokine receptor expression on CD27+ and CD27- switch memory B cells delineated potential mechanisms for their recruitment to the inflamed joints.
Methods- B cells from synovial fluid (SF) and peripheral blood (PB) of 25 JIA patients, as well as from PB of 20 controls of comparable age, characterized by multi color flow cytometry
- Immunoglobulin-secreting cells were detected by ELISPOT
- Immunohistochemical analyses of synovial tissue from 3 JIA patients performed
- JIA SF B cells enriched in CD27+ and CD27- switch memory B cells, but not in CD27+ IgM memory B cells, compared to patient and control PB
- Plasma blasts more abundant in SF and secreted higher amounts of IgG.
- Lymphoid aggregates not organized in follicle-like structure detected in synovial tissue sections and surrounded by CD138+ plasma cells
- Transitional B cells significantly increased in JIA PB vs SF or control PB
- CCR5, CCR8, CXCR2, and CXCR3 were up-regulated, whereas CCR6, CCR7, and CXCR5 were down-regulated on SF CD27+ and CD27- switch memory B cells compared with circulating counterparts
- SF CD27+ and CD27- switch memory B cells expressed at high levels costimulatory molecule CD86 and activation marker CD69
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