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Termine C et al. – A proportion, at least, of the migraine with aura (MA) patients showed a more complex phenotype characterized by mitral valve prolapse (MVP) and/or positive anticardiolipin antibodies (aCL) titres. The pathogenetic role of these associations is obscure and larger studies are needed to confirm the usefulness of echocardiographic and laboratory investigations in this area and to identify possible new treatment approaches that might be explored in this group of MA patients.

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