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Dexmedetomidine pharmacokinetics in pediatric intensive care – a pooled analysis
Paediatric Anaesthesia, 10/13/09
Potts AL et al. – The sedation target concentration is similar to that described for adults. Immature clearance in the first year of life and a higher clearance in small children dictate infusion rates that change with age. Extrapolation of dose from children given infusion in intensive care after cardiac surgery may not be applicable to those sedated for noninvasive procedures out of intensive care.
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