Pediatrics Medical News about Bacteremia

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Bacteremia in febrile nonneutropenic pediatric oncology patients
Pediatric Blood & Cancer, 10/14/09

Kelly MJ et al. – Bacteremia is an important issue in febrile nonneutropenic pediatric oncology patients occurring in 6% of the patient visits in this study. The overall sensitivity of high–risk bacteremia to ceftriaxone provides justification for its empiric use in outpatient febrile nonneutropenic pediatric oncology patients.

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Michael J. Kelly , 10/15/09

Nonneutropenic fever is a rather common clinical scenario in pediatric oncology. However, there have been few studies to guide management. This study demonstrates that bacteremia is not uncommon in this population and that these patients become bacteremic with a variety of both gram positive and gram negative organisms. It is encouraging that almost all of the high-risk organisms had at least an intermediate sensitivity to ceftriaxone, a common empiric antitibiotic choice in this scenario. Also, patients with external central lines (Broviacs or Hickmans) had a higher odds of having bacteremia compared to patients with ports. None of the patients with a source for fever on exam were bacteremic. This paper should help guide pediatric oncologists in managing this common clinical problem.

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