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See Latest ArticlesThe Myotonias and Susceptibility to Malignant Hyperthermia
Anesthesia & Analgesia, 09/18/09
Parness J et al. – Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle in which volatile anesthetics trigger a sustained increase in intramyoplasmic Ca2+ via release from sarcoplasmic reticulum and, possibly, entry from the extracellular milieu that leads to hypermetabolism, muscle rigidity, rhabdomyolysis, and death.
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