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A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia
Leukemia, 09/14/09

Hijiya N et al. – The combination of clofarabine, etoposide and cyclophosphamide was well tolerated and effective in pediatric patients with relapsed/refractory leukemia.

• 3 drugs were administered for 5 consecutive days in induction
• Drugs administered four consecutive days in consolidation
• Maximum eight cycles
• 20 ALL and 5 AML patients were enrolled in five cohorts

• CR was achieved in 10 patients (ALL: nine; AML: one)
• CR without platelet recovery in six patients (ALL: two; AML: four)
• Overall response rate of 64% (ALL: 55%; AML: 100%)
• Of 16 responders, 9 patients proceeded to hematopoietic SCT

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