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See Latest ArticlesSerum osteopontin as a predictive marker of responsiveness to methotrexate in juvenile idiopathic arthritis
Journal of Rheumatology, 09/11/09
Masi L et al. – Serum levels of OPN at baseline represent a possible marker to predict the responsiveness to MTX in patients with JIA.
Methods- At diagnosis, 60 children with active JIA received MTX in addition to nonsteroidal antiinflammatory drugs
- After 12 months of MTX treatment, 30 patients were defined as responders; the 30 nonresponders received anti-tumor necrosis factor-? therapy (etanercept) in addition to MTX; this group was then enrolled for an additional 12-month study period
- No patient had received steroids within 6 weeks before entering the study
- Fifty healthy children matched for sex and age acted as controls
- OPN serum levels were measured at baseline, before MTX, and then at 6 and 12 months
- In the nonresponder patients, OPN was evaluated again after 6 and 12 months of etanercept treatment
- At baseline, OPN values were significantly higher in JIA patients than in controls, with no significant differences among the different JIA subtypes
- At baseline, OPN levels were lower in responders than in nonresponder patients (14.16 ± 10.1 µg/ml vs 33.2 ± 18.1 µg/ml, respectively)
- After 12 months of MTX treatment, OPN levels were significantly reduced in comparison to baseline in both responder and non-responder groups
- In non-responders, etanercept significantly reduced OPN levels at 6 and 12-month followup in comparison to baseline
- No significant differences were found among OPN levels and disease activity
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