Pediatrics Medical News about juvenile idiopathic arthritis;purified protein derivative response

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Purified protein derivative response in juvenile idiopathic arthritis
Journal of Rheumatology, 09/09/09

Kasapcopu O et al. – The response to PPD, which is one of the Th1 cell-type responses, was significantly lower in BCG-vaccinated children with JIA compared to healthy children.

Methods

PPD skin test was performed in 115 children with JIA who were vaccinated with bacillus Calmette-Guerin (BCG), and then they were compared to the PPD response of 45 healthy children of the same age who were vaccinated with BCG
Children with a PPD induration ? 5 mm were accepted as PPD-positive. PPD induration ? 10 mm was accepted as a limit for suspecting tuberculosis

Results

PPD induration size and PPD positivity rates (PPD ? 5 mm) of children with JIA were significantly lower than those of healthy children
The mean of PPD induration size was significantly lower (p < 0.0001) in patients with either 1 BCG vaccine (3.7 ± 3.6) or more than 1 BCG vaccine than controls with either 1 BCG vaccine (7.10 ± 3.2) or more than 1 BCG vaccine (10.05 ± 4.1)
PPD was positive in 35.9% of patients with JIA vaccinated once (n = 32), in 50% of patients with JIA vaccinated more than once (n = 13), in 82.1% of controls vaccinated once (n = 23), and in 88.2% of controls vaccinated more than once
It was determined that neither the activity of the disease nor the use of corticosteroid and methotrexate affected the PPD response

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