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See Latest Articles2-chlorodeoxyadenosine (2-CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). results of the LCH-S-98 protocol of the histiocyte society
Pediatric Blood & Cancer, 09/28/09
Weitzman S et al. – 2–CdA is active in LCH. It produces a higher response rate in patients with low–risk multisystem or multifocal bone disease than those with risk organ involvement. Risk patients who fail to respond to 2–CdA have a high mortality. Patient age at 2–CdA therapy and length of time from diagnosis to 2–CdA significantly affect response and survival.
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