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Klein VC et al. – Higher biobehavioral reactivity to pain and distress predicted higher temperamental Negative Affect, above and beyond gestational age, illness severity and amount of pain exposure in NICU. However, the authors did not find a predictive relation between gestational age, CRIB score and number of painful procedures undergone NICU and toddler's temperament. The findings highlight the relevance of the neonatal individual characteristics of reactivity for identifying more vulnerable infants for future problems in biobehavioral regulation.

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