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Diffner E et al. – These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre–B ALL patients had significantly increased expression of VEGFR–1 compared with no expression in the nonmalignant group, indicating a link between VEGFR–1 protein expression and pre–B ALL. These novel findings suggest that VEGFR–1 may have clinical importance in childhood pre–B ALL.


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