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Taketani T et al. – Bone marrow examination revealed markedly decreased erythropoiesis with cytoplasmic vacuolation of erythroblasts. Anemia recovered 19 days after cessation of LZD. Elevated protoporphyrin and a high LZD level in the blood suggested that mitochondrial disturbance by high–dose and long–term treatment with LZD may have been responsible for LZD–induced pure red cell precursor toxicity.

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