Pediatrics Medical News about nonalcoholic fatty liver disease; metabolic syndrome; children

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The metabolic syndrome and nonalcoholic fatty liver disease in children
Current Opinion in Pediatrics, 08/26/09

Sundaram S et al. – NAFLD occurs with a high prevalence and severity in obese, insulin–resistant adolescents, especially Hispanic males. Pediatric NAFLD may improve with lifestyle therapy and agents that improve insulin sensitivity. In youth, NAFLD appears tightly correlated with components of the MetS, especially visceral fat, which appears to predict fibrosis as well as liver fat. In addition, noninvasive techniques such as transient elastography may help provide data on fibrosis in youth with NAFLD and avoid biopsy. The close association between NAFLD and the MetS supports screening for other comorbidities associated with the MetS. Further research is urgently required to best identify effective therapies to prevent and treat NAFLD, but its close association with MetS argues for a focus on strategies designed to improve insulin resistance and components of the MetS.

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