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Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children
Journal of Immunology, 08/20/09
Subrata LS et al. – Findings suggest that respiratory viral infection in atopic children may initiate an atopy–dependent cascade that amplifies and sustains airway inflammation initiated by innate antiviral immunity via harnessing underlying atopy–associated mechanisms. These interactions may account for the unique susceptibility of atopics to severe viral–induced asthma exacerbations.
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