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See Latest ArticlesDopamine therapy promotes cerebral flow-metabolism coupling in preterm infants
Intensive Care Medicine, 08/04/09
Wong FY et al. – Cerebral blood flow–metabolism coupling in the very preterm brain differs strikingly from that in the mature brain, where CBF is coupled to CMRO2. In the very preterm brain, variations of cerebral oxygen extraction, not CBF, sustain CMRO2. In contrast, preterm infants receiving dopamine exhibit flow–metabolism coupling similar to the mature brain. These findings suggest a previously unrecognised role for dopamine in the preterm brain in promoting flow–metabolism coupling.
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