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Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a canadian multicenter, prospective inception cohort study
Arthritis Care and Research , 08/07/09

Oen K et al. – Data show that clinical measures soon after diagnosis predict short-term outcomes for patients with juvenile idiopathic arthritis (JIA). The Juvenile Arthritis Quality of Life Questionnaire (JAQQ) is a predictor of multiple outcomes; time to diagnosis affects quality of life in the short term.

• Study to determine early predictors of 6-mo outcomes in a prospective cohort of pts with JIA
• Pts selected were those enrolled in an inception cohort study of JIA within 6 mo after diagnosis
• The juvenile rheumatoid arthritis core criteria set and quality of life measures were collected at enrollment and 6 mo later
• Outcomes evaluated included inactive disease, JAQQ scores, and Childhood Health Assessment Questionnaire (C-HAQ) scores at 6 mo

• 33% of pts had inactive disease at 6 mo
• Onset subtype and most baseline core criteria set measures correlated with all 3 outcomes
• Relative to oligoarticular JIA, the risks of inactive disease were lower for enthesitis-related arthritis, polyarthritis RF-negative JIA, and polyarthritis RF-positive JIA, and were similar for psoriatic arthritis
• In multiple regression analyses, the baseline JAQQ score was an independent predictor of all 3 outcomes
• Other independent baseline predictors included:
  • Polyarthritis RF-negative and systemic JIA for inactive disease
  • C-HAQ score and polyarthritis RF-positive JIA for the 6-mo C-HAQ score
  • Active joint count, pain, and time to diagnosis for the 6-mo JAQQ score

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