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Marceau JR et al. – This study found no differences in the pain responses of ME infants and non–exposed infants when given sucrose during heel lance procedures.

Exclusive Author Commentary
James R. Marceau, 08/05/09

It was previously thought that for taste-inducde analgesia to occur in the infant, it must firstly have a functional endogenous opioid system; this was base on one small observational study of four methadone-exposed infants. However, oral sucrose has been demonstrated to attentuate opiate withdrawal symptoms in opiate dependent rats. Whether oral sucrose has the potential to attentuate opiate withdrawal or even exhibit analgesic effects has not been systemetically investigated. This prompted us to take the first step to establish that sucrose has an anlgesic effect in infants of methadone-maintained mothers

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