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Successful sulfonylurea treatment of an insulin-naive neonate with diabetes mellitus due to a KCNJ11 mutation
Pediatric Diabetes, 07/30/09

Wambach JA et al. – This is the youngest NDM patient to receive oral glyburide and, importantly, the only one deliberately initiated on sulfonylureas. Strikingly, the current dose is below the reported therapeutic range and approximately 75-fold lower than doses required by the affected sister and mother. Safe and effective initiation of glyburide in an insulin–naive neonatal patient with KATP–dependent PNDM argues for early detection and sulfonylurea intervention.

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