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See Latest ArticlesAberrant methylation and reduced expression of RASSF1A in Ewing sarcoma
Pediatric Blood & Cancer, 08/05/09
Avigad S et al. – A significant correlation of methylation to reduced expression of RASSF1A was observed in 12 ES tumors analyzed and in all cell lines. ES patients with methylated RASSF1A had worse prognosis compared to the unmethylated group. Treatment with 5–aza–2'–deoxycytidine resulted in the re–expression of the unmethylated form of RASSF1A in two ES cell lines.RASSF1A is frequently methylated in ES.
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