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See Latest ArticlesPeripubertal estrogen levels and physical activity affect femur geometry in young adult women
Osteoporosis International, 07/15/09
Devlin MJ et al. – Study suggests that both physical activity and peripubertal estrogen have important influences on young adult bone strength and that hormone levels may be mediators of human osteogenic responses to exercise.
Methods- An investigation of how peripubertal estrogen affects skeletal responses to exercise in young females
- Data from 84 participants in the Penn State Young Women's Health Study to test the prediction that young women who:
- Had higher E2 levels during the first year after menarche or
- Were more physically active in adolescence
- will have greater bone strength at the end of adolescence
- Subjects were divided into tertiles of physical activity and of E2 level in the first, second, and third postmenarchal yrs
- Femoral strength was calculated from DEXA scans of the proximal femur using hip structure analysis
- At age 17, subjects with the highest E2 levels in year 1 after menarche had 5-14% greater strength in the narrow neck and intertrochanteric region
- Most active subjects had 10–11% greater strength in the femoral narrow neck vs less active girls
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