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Hansen TWR et al. - Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.

Exclusive Author Commentary
Thor Willy Ruud Hansen, 07/10/09

This paper underlines the importance of treating neonates with extreme jaundice as an emergency procedure. Even when neurological signs and symptoms are present, reversibility may be possible. Phototherapy should be started STAT without waiting for TSB values. The stongest possible light on the largest possible skin surface! STAT blood samples for type & cross in order to obtain blood for an exchange transfusion. Start 0,5-1 G/kg intravenous immune globulin if any information in the case history is suggestive of blood group incompatibility. Enteral feeding (if not clearly contraindicated by clinical state) with liberal amounts of breast milk substitute (e.g. Nutramigen).

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