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See Latest ArticlesSerologic follow-up of children born to mothers with Ro/SSA autoantibodies
Lupus, 07/17/09
Klauninger R et al. – These findings support a role for placental materno-foetal transfer of IgG autoantibodies in the pathogenesis of neonatal lupus erythematosus (NLE) and indicate that refraining from breastfeeding does not protect from NLE skin involvement.
Methods- An investigation of the postnatal Ro and La IgG, IgA and IgM antibody levels up to 1 year of age in 32 children born to Ro/SSA positive mothers
- Antibody levels were correlated with NLE manifestations
- Role of breast feeding in transfer of autoantibodies from mother to child was evaluated
- Ro52, Ro60 and La IgG Abs all transferred from the mothers to their foetus in utero and were present in the infant at birth
- A significant decrease in Ro52, Ro60 and La IgG Ab levels of the infants was observed from birth to 4-5 wks of age
- Ro- and La-specific IgA and IgM Abs were detected in the serum from a subset of mothers
- However, Ro- and La-specific IgA and IgM Ab levels were low or non-detectable in children raised both with and w/o breastfeeding
- Furthermore, NLE skin lesions developed independently of breastfeeding
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