Pediatrics Medical News about Down syndrome

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Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populations
American Journal of Medical Genetics, 06/30/09

Ghosh S et al. - The authors observed an association between meiosis I nondisjuncion and recombination in the telomeric 5.1 Mb of chromosome 21. Overall reduction of recombination irrespective of maternal age is also evident in meiosis I cases. This not only provides much needed confirmation of previous results, but it suggests that the genetic etiology underlying the occurrence of trisomy 21 may be similar across human populations.

Exclusive Author Commentary
Subrata Kumar Dey, 07/24/09

Results of our investigaton proves beyhond doubt that reduced recombination is one of the important cause of nondisjunction during meiosis.However,we intend to continue the investigation with larger sample size and markers.

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Catastrophic antiphospholipid syndrome in a patient with Down syndrome
Lupus, 10/05/09 Relevance Score: 69%%

Ethnic differences in considerations whether or not to participate in prenatal screening for Down syndrome
Prenatal Diagnosis, 10/21/09 Relevance Score: 68%%

Ductus venosus pulsatility index as an antenatal screening marker for Down's syndrome: use with the Combined and Integrated tests
Journal of Medical Screening, 10/07/09 Relevance Score: 68%%

First-trimester Down syndrome screening in women younger than 35 years old and cost-effectiveness analysis in Taiwan population
Journal of Evaluation in Clinical Practice, 10/07/09 Relevance Score: 68%%

Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome
Prenatal Diagnosis, 10/22/09 Relevance Score: 67%%