Pediatrics Medical News about polyarticular juvenile idiopathic arthritis;inactive disease

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Inactive disease in polyarticular juvenile idiopathic arthritis: Current patterns and associations
Rheumatology, 06/22/09

Ringold S et al. – Study reports that children with polyarticular juvenile idiopathic arthritis (JIA) spent the majority of their follow-up with active disease; improving outcomes for these subgroups may be an important goal for prospective study.

Methods

Study was undertaken to:
- Describe the achievement of inactive disease (ID) and remission in JIA and
- Measure the associations among patient characteristics, imaging results and these outcomes
Cohort study of children (n=104) with polyarticular JIA diagnosed and treated between Jan 2000 and Dec 2006
Each pt's disease status (active disease vs ID) was determined for every clinic visit
Adjusted relative risk estimates were obtained using Mantel–Haenszel methods

Results

Pts were followed up for an average of 30 mo
Pts achieved 138 episodes of ID; 51 pts achieved 69 episodes of clinical remission on medication
When duration of active disease was summed over each pt's f/u, pts spent a mean of 66.3% of their f/u with active disease
Pts with evidence of joint damage on imaging studies obtained within 6 mo of their first clinic visit spent a mean of 79% of their f/u with active disease
Pts w/o these findings spent a mean of 58.5% of their f/u with active disease
Children who were RF+ and children with early evidence of joint damage had higher prevalence of active disease during the f/u

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