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Mandel ED - B19 infection is a vital addition to the differential diagnosis, whether the patient has a suspected virus-related illness or a condition not classically considered viral in etiology, such as the four cases presented in this article. In addition, questions about more widespread screening of blood products, pregnant women, and even vaccine development exist for clinicians to consider. The many faces of B19, as well as other emerging members of the Parvoviridae family, can challenge the best diagnostician. Therefore, maintaining an index of suspicion for this tiny virus is good medicine.



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