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Scott LK et al. – Results of a limited pt series show ziprasidone as safe and effective in pediatric pts with closed head injuries who develop agitation and/or aggression in immediately postinjury. Ziprasidone consistently lowered Riker Sedation-Agitation Scale (SAS) scores in all age groups, with minimal dose adjustments, brief duration of therapy, and no adverse events. A prospective trial of ziprasidone in this population is warranted.

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