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Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population
Pediatric Allergy and Immunology, 05/29/09
Muller S et al. - The authors found a highly significant association of the FLG null variants R501X- and 2282del4 with AD and asthma. The replication and its statistical significance underlines the importance of the FLG polymorphisms and the importance of the skin barrier function in the development of AD and subsequent asthma.
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