The High Rate of Adverse Drug Events in Children Receiving Prolonged Outpatient Parenteral Antibiotic Therapy for Osteomyelitis Faden BA et al. - Forty-five children treated with 82 courses of 15 different antibiotics over 344 weeks during outpatient parenteral antibiotic therapy were evaluated for adverse drug events. Fifty-one percent of the courses had an associated ADE and 32.5% of the antibiotic courses were discontinued because of ADE. Vancomycin had the highest ADE rate at 85.7% and ceftriaxone had the highest ADE-related discontinuation rate at 66.7%. Cefazolin had the lowest rate of ADE and ADE-related discontinuation rates at 0% for both. [more...]
