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See Latest ArticlesEffect of Obesity on Platelet Reactivity and Response to Low-Dose Aspirin
Preventive Cardiology, 12/15/09
Bordeaux BC et al. – Obese individuals had greater baseline platelet reactivity. Comparing obese and nonobese individuals after aspirin therapy, results for aggregometry to collagen were 6.7 vs 6.1 ohms, P=.008; aggregometry to adenosine diphosphate were 13.1 vs 11.8 ohms, P<.0001; aggregometry to arachidonic acid (AA) were 4.9% vs 8.3% nonzero aggregation, P=.002; urinary excretion of 11–dehydro–thromboxane B2 (Tx–M) were 4.9% vs 8.3% nonzero aggregation, P=.002; and aspirin resistance were 26.% vs 20.5%, P=.002; respectively. These remained significantly different for AA aggregation and Tx–M excretion after adjustment for covariates. Obese individuals have greater native platelet reactivity and retain greater reactivity after suppression by aspirin.
Bryan Bordeaux, 12/15/09
| We believe that this is an important study because it evaluated platelet function before and after low dose aspirin in obese and nonobese individuals from families with an increased risk of cardiovascular disease. We found that obese individuals appear to have increased baseline platelet aggregation and that low dose aspirin does not appear to be as effective at preventing platelet reactivity. More research is needed to determine the optimal antiplatelet medication and dosing for cardiovascular disease prevention in obese individuals. |
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