PA Medical News about Analgesics NICU sedative drugs

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Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data
Pediatric Research, 11/09/09

Durrmeyer X et al. – This review summarizes current experimental knowledge on the effects of sedative and analgesic drugs on brain development and reviews clinical evidence that speaks for or against the use of common analgesic and sedative drugs in the NICU, but avoids any discussion of anesthesia during surgery. Risk/benefit ratios of intermittent boluses or continuous infusions for the commonly used sedative and analgesic agents are discussed in the light of clinical and experimental studies. The limitations of extrapolating experimental results from animals to humans must be considered while making practical recommendations based on the currently available evidence.