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Short Communication: The Dead Cell: A Potent Escort for HIV Type 1 Transinfection
AIDS Research and Human Retroviruses, 11/09/09

Sealy R et al. – Confirmatory experiments were conducted with more than one target cell and more than one source of HIV–1. Results demonstrated that there may be multiple cell types and mechanisms with which transinfection can be accomplished. Apparently the simple binding of fragmented escort membranes to HIV–1 may be sufficient to enhance virus fusion or endocytosis at the target cell surface. The fact that dead cells or membranes can support this activity may explain, at least in part, the high frequency of human HIV–1 infections at sites of tissue damage.