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HIV Type 1 Subtype A Envelope Genetic Evolution in a Slow Progressing Individual with Consistent Broadly Neutralizing Antibodies
AIDS Research and Human Retroviruses, 11/09/09

Dieltjens T et al. – Major V1 Env sequence expansion, variation by a duplication event, and cumulative addition of cysteine residues and potential N–glycosylation sites over time may contribute to escape from antibody pressure directed to Env receptor domains by changing the exposure of neutralization–sensitive epitopes. Conservation of functional epitopes may correlate with the continued presence of broad cross–neutralizing antibodies.