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Peptidylarginine deiminases and the pathogenesis of rheumatoid arthritis: A reflection of the involvement of transglutaminase in coeliac disease
European Journal of Internal Medicine , 11/06/09
Stenberg P et al. – Possible mechanisms of the effects of cigarette smoking and alcohol consumption on RA are discussed. By reflecting the progress in CD, the pathogenesis of ACPA–positive RA can be hypothesized where expression and regulation of PADs play significant roles. Indeed, autoimmune diseases should be studied collectively as well as individually. The new insight may lead towards innovative pharmacotherapeutic principles.
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