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See Latest ArticlesThe anti-oxidant capacity of tumour glycolysis
International Journal of Radiation Biology, 11/05/09
Sattler UGA et al. – Transactivation of tumour glycolyis appears to generate a chemically reduced milieu associated with an inhibition of ROS–mediated fixation of DNA damage and induction of radioresistance. Furthermore, highly glycolytic cells enhance the antioxidant defense via glutathione, and pyruvate can be decarboxylated non–enzymatically upon reducing hydrogen peroxide. The summary of data given here emphasises the importance of further research efforts on the link between carbohydrate metabolism and redox state of cancer cells.
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