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Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
Proceedings of the National Academy of Sciences of the United States of America, 11/04/09

Sears DD et al. – Pre–TZD treatment expression of MLXIP in muscle and HLA–DRB1 in adipose tissue from insulin resistant subjects was linearly predictive of post–TZD insulin sensitization. We have uniquely characterized coordinated cellular and tissue functional pathways that are characteristic of insulin resistance, TZD–induced insulin sensitization, and potential TZD responsiveness.

Evolution, body composition, insulin receptor competition, and insulin resistance
Preventive Medicine, 11/02/09 Relevance Score: 97%

Comparison of Prandial AIR Inhaled Insulin Alone to Intensified Insulin Glargine Alone and to AIR Insulin Plus Intensified Insulin Glargine in Patients with Type 2 Diabetes Previously Treated with Once-Daily Insulin Glargine
Diabetes Technology & Therapeutics, 10/05/09 Relevance Score: 96%

U-500 Regular Insulin: Clinical Experience and Pharmacokinetics in Obese, Severely Insulin Resistant Type 2 Diabetic Patients
Diabetes Care, 11/16/09 Relevance Score: 95%

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation
Endocrinology, 11/06/09 Relevance Score: 94%

Initiation of Prandial Insulin Therapy with AIR Inhaled Insulin or Insulin Lispro in Patients with Type 2 Diabetes: A Randomized Noninferiority Trial
Diabetes Technology & Therapeutics, 10/02/09 Relevance Score: 94%