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National Institutes of Health State-of-the-Science Conference Statement: Family History and Improving Health
Annals of Internal Medicine, 11/04/09

Berg AO et al. – The panel recognized that family history has an important role in the practice of medicine and may motivate positive lifestyle changes, enhance individual empowerment, and influence clinical interventions. The panel found that it is unclear how this information can be effectively gathered and used in the primary care setting for common diseases. The emerging international paradigm on using evidence–based methods to evaluate tests and interventions works best when one can trace a linear pathway from test development through randomized, controlled trials that anchor usefulness in clinical practice with quantitative evidence of benefits and harms—principles best exemplified in the field of genetics by the ACCE Model Process for Evaluating Genetic Tests (www.cdc.gov/genomics/gtesting/ACCE/index.htm) and Evaluation of Genomic Applications in Practice and Prevention (www.egappreviews.org) methods. For a systematically collected family history for common diseases to become an evidence–based tool in primary care clinical settings, substantial additional research is needed. Challenges include the number, complexity, and cost of rigorous studies that can adequately address the scientific questions outlined in this panel's research recommendations.

Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Womens Health Initiative Observational Study
Diabetes/Metabolism Research and Reviews, 10/12/09 Relevance Score: 80%

Deficits in Affective Prosody Comprehension: Family History of Alcoholism versus Alcohol Exposure
Alcohol and Alcoholism, 10/12/09 Relevance Score: 80%

Mammographic Screening and Risk Factors for Breast Cancer
American Journal of Epidemiology, 10/30/09 Relevance Score: 79%

Preventing future cancers by testing women with ovarian cancer for brca mutations
Journal of Clinical Oncology, 10/22/09 Relevance Score: 79%

Serious Emotional Disturbance Among Youths Exposed to Hurricane Katrina 2 Years Postdisaster
Journal of the American Academy of Child and Adolescent Psychiatry, 10/08/09 Relevance Score: 79%