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Pediatric Safety of Tizanidine: Clinical Adverse Event Database and Retrospective Chart Assessment
Pediatric Drugs, 11/10/09

Henney HR et al. – The overall safety of tizanidine in the pediatric group appeared good; however, the adverse event profile differed from that in adults. This difference most likely reflects the off–label use of tizanidine as adjunctive treatment for attention disorders and autism. The frequency and nature of adverse events in adults were consistent with the tizanidine prescribing information as reported for its approved indication, i.e. management of spasticity.