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Dynamics of body composition and bone in patients with juvenile idiopathic arthritis treated with growth hormone
Journal of Clinical Endocrinology and Metabolism, 11/09/09

Bechtold S et al. – During GH treatment, there was a significant increase and normalization of total bone and muscle CSA at final height. In accordance with an anabolic effect of GH, fat mass stabilized at the lower limit of healthy children. At final height, cortical and marrow CSA, relative to total bone CSA, were normalized in GH-treated patients.

Methods

Longitudinal study
Parameters of bone mineral density and geometry as well as muscle and fat cross-sectional area (CSA) in nondominant forearm recorded using peripheral quantitative computed tomography at yearly intervals until final height in 12 patients (seven females) receiving GH treatment
Data at final height compared with 13 patients (nine females) with JIA not treated with GH

Results

Patients treated with GH for mean of 5.35 ± 0.7 y
Correcting for height, total bone CSA (+0.89 ± 0.5 SD) and muscle CSA (+1.14 ± 0.6 SD) increased significantly and normalized at final height
Compared with JIA patients without GH at final height, there was significantly higher muscle CSA and lower fat CSA in GH-treated patients
In relation to total bone CSA, there was significantly more cortical and less marrow CSA in boys with GH treatment